Continue modding in F3 or switch to TTW?

[BasedTelemancer]

I have been developing a mod for Fallout 3. I haven't gotten very far, mostly been aggregating guns and thinking things through trying to solidify my ideas, as I have a very particular vision of what I would like Fallout 3 to be. It would include making combat more entertaining and engaging (mostly through changes to the weapons so far), making survival, medicine, healing, and the economy a more active feature of gameplay, and in the end (if life, sanity, and our simultaneous lover and tormentor, the engine, will allow) an overhaul of the factions and story in order to rectify what I see as a giant squandered opportunity on Bethesda's half. I would try to implement this in the least intrusive way possible, but I'm no Gamebryo scientist so I'm not even sure what that means.

However in order to do this in a way I'd be happy with I need a lot of the features and animations that New Vegas added, and it dawns on me more and more that trying to cram them into Fallout 3 with mods (many of which are very old and probably incredibly icky under the hood) is gonna lead to a giant sticky mess that's very likely to cost me a lot of time and effort in the future if I go through with this.

So my question is, would it be easier to do this by modding TTW with these features already native, or would I be better off continuing with Fallout 3?
Would such a mod even be possible with TTW? Would the changes you introduced (whatever they may be) already be too substantial to make such a pursuit even realistically feasible?

I've been on the fence about this for a while now as I'd rather not go too far in either direction and have to either give up or redo all of my work from scratch if I hit an impassable obstacle.