@Roy, Thanks for all the great advice. By following your guidelines (like not cleaning the masters), the game is incredibly stable considering it's an early Beth offering (to me, it's still in it's infancy in may ways. Not to sound condescending. Speaking of NVSR, I noticed that (Out of Memory errors) when using the "5" setting, but not with the "6", though it'll probably happen soon enough. Especially if it removes something that the game engine tries to clear, and is returning a negative or astronomically incorrect value. I'm wondering though, if it's acting differently for different makes/models of cpus. Where games seem to be more optimized for Intels line up, not AMDs, and may behave differently from each other. I went AMD since I needed to build at least 3 systems for me and the kids, and that was the cheaper option for me. I'll get a stretch of testing done here if I'm able and see if I can pull out the "Out of Memory" error.
@pintocat, I'm running ultra settings, HD textures, mods, Vurts, MMM and @1776x1000 (anything else will cause clipping on the borders, which is the fault of this older tv rather than the gpu. Since there isn't an overscan option on the tv. 1080+ is ok, but I don't really like the clipping effect so I don't use it). Not using a multi-monitor. The gpu isn't being completely utilized (about 1/2) while the cpu cores are spiking back and forth, which, to me, is the bottle neck. I don't want to overclock the cpu yet, until I get a liquid cooler installed (it's breathing air atm), then I'll move it more towards the 4.8-5 if i can push it, range, and see what that does. The cpu, as it is, can fluctuate it's clock to keep itself cool (which isn't optimum, but it'll have to do for now). I locked the refresh rate at 50 through NVSR, though outdoors it seems to fluctuate between low 30's to mid 40's depending on where I am in the DC area. Indoors, it's usually pinned at 50. Running Windows 7 64 and haven't tried using compatibility mode though to see what might happen FPS wise.
Slowly getting everything debugged somewhat. At the beginning of the game (haven't disabled the mods until I'm out of Vault 101, which might be causing a problem since I'm seeing Enclave commander report twice that it's starting up (I'm hoping the script is setup with a check so it won't have two occurances of itself running).