I am having a similar issue which only started after I installed an ENB. It was all working fine while I was in the metro then i exited at Wilhelm's Wharf, killed the talon mercs and went to loot them but the menu wouldn't open. opened the pip-boy and all weapons except NVSE's flashlight and the Binoculars were just exclamation marks and no icons as were all non headgear, modded aid and Misc. I Reloaded before exiting the Metro, everything fine; exited metro, everything still fine; move away from metro, broken. reloaded a save before leaving vault 101, same thing happened before I even reached Springvale.
I tried resetting Archive Invalidation, No ENB (thought it was a memory issue). not sure what else to try as the meshes are there, and then not.
[collapsed title=Load Order]
FalloutNV.esm=1
DeadMoney.esm=1
HonestHearts.esm=1
OldWorldBlues.esm=1
LonesomeRoad.esm=1
GunRunnersArsenal.esm=1
CaravanPack.esm=1
ClassicPack.esm=1
MercenaryPack.esm=1
TribalPack.esm=1
Fallout3.esm=1
Anchorage.esm=1
ThePitt.esm=1
BrokenSteel.esm=1
PointLookout.esm=1
Zeta.esm=1
TaleOfTwoWastelands.esm=1
TTWFixes.esm=1
Interior Lighting Overhaul - Core.esm=1
FreesideOpen.esm=1
NVInteriors_Core.esm=0
TTWInteriors_Core.esm=1
TTWInteriorsProject_Combo.esm=1
NVInteriors_ComboEdition.esm=0
StreetLights.esm=1
OutsideBets.esm=1
DFB - Random Encounters.esm=1
Mothership Crew.esm=1
NVStripOpen.esm=1
Moddable Unique Weps.esm=0
Companion Core.esm=1
RobCo Certified.esm=1
Freeside Open - TTW.esm=1
Voyager.esm=1
BBBackpacks.esm=1
Project Nevada - Core.esm=1
MikotoBeauty.esm=1
Ambient Temperature.esm=1
Inventory Access.esm=1
Moddable Unique Weps.esp=0
Outcast DX.esp=0
BoSDX.esp=0
Tribal_DX.esp=0
WinterizedT51bDX.esp=0
Project Nevada - Equipment.esm=1
Project Nevada - Rebalance.esp=1
Project Nevada - Cyberware.esp=1
Project Nevada - Extra Options.esm=1
oHUD.esm=1
Interior Lighting Overhaul - Ultimate Edition.esp=1
50MGHE.esp=1
Vurt's WFO.esp=1
Root 'n Loot.esp=1
Project Nevada - Rebalance Complete.esp=1
Project Nevada - All DLC.esp=1
WeaponModsExpanded.esp=1
Busworld.esp=1
Project Nevada - TTW.esp=1
WMX-DLCMerged.esp=1
WMX-FOOKNV-DLCMerged CP.esp=0
ttwspeechchecks.esp=0
TTW_SpeechChecks.esp=1
ColossusArmor.esp=1
DEFAULT.esp=1
DFB - Random Encounters - Update - MCM.esp=1
Flora Overhaul.esp=1
kochandbohr.esp=1
WMX-FOOKNV CP.esp=0
betsybrahminFSO.esp=1
TTW_Reputation.esp=1
ttw_wildwasteland.esp=1
TTWOptions.esp=1
USSHoodwink.esp=1
FreesideOpen - StreetLights.esp=1
TTW Realistic Wasteland Lighting - Enhanced.esp=1
ILO - Tale of Two Wastelands.esp=1
Bobblehunt - Fallout 3 Bonuses.esp=1
Bobblehunt - Cap Bonuses.esp=0
Bobblehunt - Hardcore.esp=0
Bobblehunt.esp=0
TTW_BoSPatrols.esp=1
Powered Power Armor.esp=1
Bobblehunt - Hardercore.esp=0
WMX-Arwen_NV_Realism.esp=0
HHrespawn.esp=1
Armor Repair Kits.esp=1
WMX-HonestHearts.esp=1
WMX-EnergyWeaponsNoTrueIronSightsFix.esp=1
AER14 Green disintegration.esp=1
GaussCompleteBeta.esp=1
Integration - Couriers Stash+WMX.esp=1
FNV Realistic Wasteland Lighting - Enhanced.esp=0
TTW_Transportalponder.esp=1
AlienPowerCell.esp=1
TTW_Difficult_Journey.esp=1
TTWIntMojaveExpressBoxes_Combo.esp=1
Rivet City Merchants With Point Lookout.esp=1
originalintroExtended.esp=0
athornysituation.esp=1
HK PSG-1 Snipers.esp=1
Doc Mitchell's Armored Vault 21 Jumpsuit.esp=1
L96.esp=1
RaidersFA.esp=1
Kaya47NordicWeapons.esp=1
G36C_moddable.esp=1
Free Tribal Outfits.esp=1
SVD.esp=1
WMX-ModernWeapons.esp=1
Starke's Seperate Chinese Stealth Armor Helmet NV (OA Version).esp=1
Project Nevada - WMX.esp=1
DeadMoneyFemaleTuxedo.esp=1
WMX-GunRunnersArsenal.esp=0
WMX-OldWorldBlues.esp=0
WMX-DeadMoney.esp=0
WMX-LonesomeRoad.esp=0
WMX-FOOKNV-DLCs CP.esp=0
DLC Weapon Integration - WMX.esp=1
HazmatCloudImmunity.esp=1
LoadMenuTextColorChange.esp=1
MikotoBeauty.esp=1
MZAllAccessPass.esp=1
OldWorldBlues - Keep Big MT Active.esp=1
xatmosSkillPerks.esp=1
OutofVATS.esp=1
PerkEveryLevel.esp=1
RE_Alice_Outfits.esp=1
NVCassCleanerXOH.esp=1
G36C.esp=1
Cire's Facemasks.esp=1
DIM TYPE3clothesRETAIL_NV.esp=1
NVLadyoutfit1.esp=1
Starke's Seperate Chinese Stealth Armor Helmet NV.esp=0
T3_leather armors.esp=1
T3T_LCA_TTW_ImprovedNtlGuardArmory.esp=1
T3T_LCA_TTW_ImprovedWheatonArmory.esp=1
TTW_StashPackOptions.esp=1
TTW_FlashliteRecipe.esp=0
vaultgirl.esp=1
Vehicles of the Wasteland.esp=1
MZC-NPC-Tyranid-Xenomorph.esp=1
MZC Addon-Olympus Armory.esp=0
MZC Addon-Olympus Armory (forecefield).esp=1
Lookout Outfits.esp=1
PowerArmorDX.esp=1
Stealth And Recon Armor Light.esp=1
CASM with MCM.esp=1
hairberet.esp=0
K9Breeds.esp=1
K9BreedsPatchDLCPitt.esp=1
TTW_AnchorageCustomization.esp=1
K9BreedsMoreDogs.esp=1
TTW_OutcastTrading.esp=1
RobCo Certified Friendly Hit Fixer.esp=1
OWBTransportalPonder.esp=0
OWB-Path Lights - Darker Nights.esp=1
OWB-Path Lights.esp=0
Voyager - Ultimate Edition.esp=1
Voyager - TTW Edition.esp=1
WMX-ShotgunCommando.esp=0
The Weapon Mod Menu.esp=1
WMX-POPMerged.esp=0
Zan_AutoPurge_SmartAgro_NV.esp=1
Jump Fall Fixer.esp=0
Ambient Temperature - PPA.esp=1
TTW Interiors - Powered Power Armor Patch.esp=1
Project Nevada - PPA Patch.esp=1
XFO - 4bb - Perks - Two per level.esp=1
Cap Removed DR DT RR.esp=1
ILO - NVInteriors Project.esp=1
ILO - YUP Patch.esp=0
TTW Realistic Wasteland Lighting - TQL Colour.esp=1
Centered 3rd Person Camera - Unraised.esp=1
DarNifiedUINV.esp=1
Project Nevada - Dead Money.esp=0
Project Nevada - Honest Hearts.esp=0
Project Nevada - Old World Blues (No Cyberware).esp=0
Project Nevada - Lonesome Road.esp=0
Project Nevada - Gun Runners' Arsenal.esp=0
Project Nevada - Cyberware Additions.esp=1
The Mod Configuration Menu.esp=1
FlashlightNVSE.esp=1
TTW FlashlightNVSE.esp=1
TTW_Fixes_WMX_Merge.esp=1
TTW_Fixes_General_Patch.esp=1
TTW_PPA-PDX_Patch.esp=1
MergeFile.esp=1
[/collapsed]
[collapsed title=System Specs]
CPU: AMD Phenom II x4 955 BE @ 4.00Ghz
Ram: Kingston Hyper-x Fury 8GB @ 1600Mhz
OS: Windows 8.1 Pro
Mod Manager: Nexus Mod Manager [Latest]
Game Versions: NV Ultimate, FO3 GOTY [Both Steam]
[/collapsed]