As this my first post I must first congratulate the TTW team on a job very well done.
I have the "Trail of Crumbs" TTW version installed and when trying to complete the Chryslus Building quest I just get a CTD as as I try to access the lower office area of the Chryslus building.
Some of the things I tried were :-
-
I stopped all followers/companions -
Disabled all mods just leaving the core TTW files
In the end to finish the quest I had to use the console to unlock the very hard lock to the basement area (which is where I was trying to get.)
My load order is
[collapsed title=Load Order] [X] FalloutNV.esm
[X] DeadMoney.esm
[X] HonestHearts.esm
[X] OldWorldBlues.esm
[X] LonesomeRoad.esm
[X] GunRunnersArsenal.esm
[X] ClassicPack.esm
[X] MercenaryPack.esm
[X] TribalPack.esm
[X] CaravanPack.esm
[X] Fallout3.esm
[X] Anchorage.esm
[X] ThePitt.esm
[X] BrokenSteel.esm
[X] PointLookout.esm
[X] Zeta.esm
[X] TaleOfTwoWastelands.esm
[X] TTWFixes.esm
[X] Advanced Recon Tech.esm
[X] Sydney Follower.esp
[X] oHUD.esm
[X] Project Nevada - Core.esm
[X] Project Nevada - Equipment.esm
[X] Project Nevada - Rebalance.esp
[X] Project Nevada - Cyberware.esp
[X] Project Nevada - Extra Options.esm
[X] Detect Traps.esm
[X] VanessaFollowerNV.esm
[X] bittercup_comp.esp
[X] Project Nevada - Cyberware Additions.esp
[X] TTW_SpeechChecks.esp
[X] Advanced Recon Tech - Detect Traps.esp
[X] EVE FNV - ALL DLC.esp
[X] Project Nevada - TTW.esp
[X] TiesThatBind.esp
[X] CASM.esp
[X] MojaveDelight.esp
[X] Detect Traps - Perk.esp
[X] Detect Traps - Traponator 4000.esp
[X] Advanced Recon Tech.esp
[X] TTW_Bobbleheads.esp
[X] Advanced Recon Gear.esp
[X] Advanced Recon Gear - Project Nevada.esp
[X] Detect Traps - DLC.esp
[X] Project Nevada - EVE All DLC.esp
[X] Project Nevada - Rebalance Complete.esp
[X] PNxEO MCMScriptFixes.esp
[X] Project Nevada - All DLC.esp
[X] More Perks.esp
[X] A Trail of Crumbs.esp
[X] The Mod Configuration Menu.esp
[X] TTW Advanced Recon.esp
[X] TTW Perk Overhaul.esp
[X] TTW_NoKarmaDCFollowers.esp
[X] TTW_StashPackOptions.esp
[X] TTW_SuperMutantRebalance.esp
[X] VanessaTTW.esp
[X] TTW_AnchorageCustomization.esp
[X] Sydney Follower - Load Order Fix.esp
[X] sydney_follower_a55override.esp
[X] TTW_OutcastTrading.esp
[X] H&K PSG-1 Sniper Rifles.esp
[X] HalfwayHouse.esp
[X] Wasteland_Seductress.esp
[X] TTW Realistic Wasteland Lighting.esp
[X] ttw_-_custom_race_ending_fix.esp
[X] Merge patch.esp
[/collapsed]
This has been the only CTD issue I have had since playing with V2.7 & now V2.8 so hardly earth shattering 
But if someone could check to see if there is an issue with that cell or it is just my install which is slightly borked
