So I just recently ran into a problem around Megaton area. I just did a fresh install of 2.4 because I was having issues with a quest, but anyway I followed the instructions exactly as was told for the install, started up a character I had been playing for 2.2, decided to go to Megaton, and I fast traveled there. The loading screen froze. I thought it was weird so I closed the game, and tried it again with no mods. I was running just New Vegas and TTW esms. If I traveled to Springvale it would be fine but as soon as I walked the 200 yards or so to Megaton the game froze.
I'm currently running Windows 7 64 bit, 8 gigs of ram and an AMD FX 8350 processor. My version of FO 3 is GOY on steam. Using Nexus Mod Manager version .46.