Lets start with posting FO3/NV Versions, and some info:
they need to both be updated to the latest patch and in the proper folders or the patch is going to flip the F out and error like hell, because it thinks you have a modified (read: pirated) version of the game. ie: FO3 GOTY GFWL version is now mostly compatable (in previous incarnations of this mod it was not compatible at all,) but a modified/pirated version of the game is incompatible for that very reason. IE you have to actually own BOTH games and ALL DLC (Except the courier's Stash,) and they HAVE to be properly installed and UPDATED, or you'll error out.
Additionally, you'll have to have actually read through the download page and have made the requisite downloads and installations. If this is done previously you can skip this part. If you are unsure if these installations have been made on your machine DO NOT skip this part.
The best way to do the install (at least for me, on my machine [W7x64]) is to UNZIP the TTW package to a folder on my desktop, though I've ran it from a folder in my downloads folder no problem as well. Install the TTW files to a files to a seperate, empty folder on your desktop then copy them to your original FNV folder.