Jumped in the simulator by playing through the main quest, and the game freezes on loading Tranquility Lane.
I searched the forum but couldn't find a definite answer to my problems. Through trial and error, I eventually track down the issue of my problem of the game freezing on the load up screen to Tranquility Lane.
The issue was Project Nevada's item sorting function and Tranquility Lane were incompatible. :(
Simply untick the item sorting function using MCM (Mod Configuration Manager) of PN Core, exit MCM, and a popup will appear saying on the next game load the items will be renamed. Save the game and exit the game. Reload the new game save, and then jump into the simulator. Fixed.
I assume after completing Tranquility Lane you can then reedit PN to turn the item sorting function back on :D
I assume this is a fix workaround for Anchorage as well, since they use a simulator too and PN item sorter might clash with that too. ;)
If you don't know what MCM is, get your head out of the sand and get it especially for Project Nevada. With MCM and PN you can edit alot of the game internals - your xp rate (mine is at 33%), perk rate, max level, carry weight, hit points, loot discovered, etc.