Yeah as you've probably read, everyone has their own preferences.
My post from that discussion thread pretty much covers it for me, although if I wanted the most immersive, but modded, experience, this would be my list:
Fixes:
-
Delay DLC - crucial for better immersion -
MTUI and then OneHUD on top of it - UI fixes (or darn UI works too) -
Mod configuration menu (required for several mods, gotta get the latest version)
Graphics Upgrades
-
NMC's texture packs for FO3 and then FNV -
Vurt's flora for FO3 and FNV -
EVE and the TTW patch -
Type 3 body, Breezes body, and associated clothes (see the FAQ)
Lighting and darker nights
-
Fellout for TTW - gets rid of weird tints and makes nights realistically dark -
Streetlights ported for TTW -
Simple streetlights for NV -
Flashlight NVSE
Additional content
-
Project Nevada and the TTW patch (can't play without it) -
WMX and the TTW patch (gotta have weapon mods) -
TTW Interiors (both of FNV and FO3 interiors mods, fits very well the the original game) -
Busworld (explorable buses)