That is unfortunate. For me the issue isn't crashing, thanks to NVAC. It's performance degredation that can be as quick as one minute of play, stuttering (even with stutter remover, it helps but still does it in places) I swear I have to PCB every few minutes, but there comes a point when even that will do no good. And things like containers and dead NPCs inventory taking a while to appear.
Related mods I'm using are NVAC, NVSE, 4GB enabler and Stutter Remover. In the ini I've tried memory tweaks like the cell buffer for more ram and the iPreloadSizeLimit, but it seems to make it worse or manifest sooner.
I love the game but I'm going to have to make this my last play through.