I have found that many mods and texture packs are using uncompressed texture files or unefficient format which can be efficiently compressed without losing quality.
I have used this tool to recompress all of New Vegas textures and it improves the game stability.
Optimizer Textures
http://skyrim.nexusmods.com/mods/12801/
It also saves a plenty of the disk space. The tool works also with skyrim and oblivion textures.
I have used it with minimum(safe) setting without problems.
