Let's be honest for a moment here- slavers provide necessary service to wasteland community, mainly converting drugged up raider bastards into productive members of society.
If anything Regulators should be running around with Mesmetrons and punishing criminals by reeducating them with hard labor for the good of innocents. Sadly these self-righteous idiots are too busy collecting fingers for some disgusting necklaces (ALLEGEDLY!!!).
Enter Paradise Falls...
You see, Paradise Falls is simply a penal colony with bad PR
AND
with a few tweaks, justice can be shown to these unsung heroes.
1)Enslaving evil and very evil NPC shouldn't be punished by karma penalty
(No Karma Penalty For Evil Slaves)
http://www.nexusmods.com/fallout3/mods/2114/?
If anything you are being the good guy here- instead of performing long-range cranial surgery, you are giving these scumbags a second chance, to prove themselves, to become better people and to think very hard about evil deeds they committed.
Now, you may think that it is noble goal and those poor humanitarians from Paradise Falls had unjustifiably slandered by simpletons who are so narrow minded they think violence is the only solution. And you'd be right.
"But there are so many of them and so few of us. I feel powerless and lost 
"
Don't despair gentle reader! There is hope for humanism yet.
2)With some encouragement you too can convince these lost souls to be part of the good fight
(FNNCQ a fallout 3 slavery overhaul)
http://www.nexusmods.com/fallout3/mods/9497/?
With a proper speech and bomb collar anyone can be convinced to tirelessly fight and work for betterment of humanity.
Delinquents and degenerates of yesterday, will be builders and heroes of tomorrow.
Together we can do it!!!
P.S. But in all seriousness these 2 mods would be good addition to TTW. As far as slave trade in Nevada goes it would be great if you could sell slaves to Legion. Heck converting slavery overhaul would be enough with additions of Legion salve market and no karma penalty for evil NPCs.
