I originally played Fallout on 360 (shame, I know. Couldn't always afford a rig that would run it.) so first and foremost I play with a controller. To that end xpadder is pretty much mandatory for me- Project Nevada Core's features on the Dpad. Combination of ILO/RLO for interior lighting. Still toying with weather mods for outside lighting/ effects URWL's pretty decent but needs alot of work for TTW.
I tend to rebuild my whole setup pretty regularly- Immersion mods, bugfix mods, enhance the core gameplay- that sort of thing. Wouldn't say I'm a loremonger, but I put a ton of time in on the original Fallouts so anything that brings TTW more in line with those are always in my load order.
Creature mods: Best I've found *that actually works with TTW* is MoMod, but again heavily modified to bring it more in line with the lore.
*shameless plug for the TTW Team*- TTWInteriors, several of Grib's mods, a couple by sesom, and any of the georgeous worldspaces TV builds are usually always in my load order. Oh, and some mod called Streetlights by SpeedyB coupled with Simple Street Lights Extra.