Thanks for the replies.
I've done a completely clean install and again all I am running is the following:
FalloutNV.esm
DeadMoney.esm
HonestHearts.esm
OldWorldBlues.esm
LonesomeRoad.esm
GunRunnersArsenal.esm
Fallout3.esm
Anchorage.esm
ThePitt.esm
BrokenSteel.esm
PointLookout.esm
Zeta.esm
TaleOfTwoWastelands.esm
TTW_MoreCookingItems.esp
TTW_NoKarmaDCFollowers.esp
TTW_StashPackOptions.esp
TTW_Bobbleheads.esp
I can get past the part where I get the Pipboy at the party, so I don't think it is related to my particular crash. It crashes at the part where you're sitting on the surgical bench and "dad" is looking at you. Before you take the GOAT. It does this even when I don't use the optional TTW.esps.
I was running such a light load order in order to get to just before you leave the cave outside Vault 101, then I was going to activate the other mods I want to use. I'll give that save game a go, was it made using only the .esms required or was there other mods too?
Thanks again.